Ντόρις Χατζηστυλιανού

Scientific Curriculum – Hadjistilianou Theodora

• Born in Volos, Greece, September 26th 1955
• Medicine Degree cum Laude at University of Siena (1979)
• Completed Residency cum laude in Ophthalmology at University of Siena (1983)
• Completed Residency in Oncology at University of Modena (1983)
• Participant at “Tumeurs oculaires de l’enfant” course, Lousanne Ophthalmic Clinic (1985)
• Participant at “Pediatric Ophthalmology-l” course, British Council, London (1988)
• PhD in “Ocular and Orbital tumoral pathology” at University of Siena (1990)
• Student at “Ophthalmic tumors molecular biology” course, Ludwig Institute for Cancer Research
• Montreal Branch (1991)
• Confirmed researcher MED/30 MALATTIE APPARATO VISIVO, 06/F2 at University of Siena
• (1990), teacher in Health-related Professions, Residency and PhD programs;
• Participant at “Clinical and Morphological effects of citotoxic and immunomodulatory drugs in Ophthalmology” updating course, Doheny Eye institute – Los Angeles (1998)
• Participant at “Uveal Melanoma conservative treatment” updating course, Genoa (2000)
• Participant at “Melanoma conservative treatment – update”, Leiden (2001)
• Participant at “Radioactive plaque placement for brachytherapy”, Lousanne (2002)
• Research Fellowship in Molecular biology – San Diego
• Research Fellowship in Retinoblastoma molecular biology – Baltimora
• High Residency in Retinoblastoma at University of Siena (2004)
• II level University Master Degree “Ophthalmoplasty and lacrimal pathways surgery”, Rome (2005)
• II level University Master Degree cum laude “Ophthalmoplastic surgery”, Naples (2009)
• S.O.I. nominated “National Expert in Oncology” (2010)
• National Scientific Qualification (ASN) as Associate Professor (2017)
• Currently confirmed Associate Professor at University of Siena (2021), teacher in Health-related
• Professions and Residency programs, chief of Retinoblastoma Referral Center at Siena Hospital and University
• Member of: Società Oftalmologica Italiana (SOI), International Society of Genetic Eye Disease and Retinoblastoma (ISGEDR), International Study Group on Retinoblastoma – board of directors, Associazione Italiana di Ematologia e Oncologia Pediatrica (AIEOP), Società Italiana di Oncologia Oculare – scientific committee, Società Internazionale di Oncologia Oculare (SIOO) – international board, Società Italiana Laser in Oftalmologia (SILO), Società Italiana di Pediatria (SIP), Società Italiana di Oftalmologia Pediatrica (SIOP), Società Italiana di Chirurgia Oftalmoplastica (SICOP), Società Europea di Oftalmologia Pediatrica (EPOS), Società Greca di Oftalmologia, Associazione Scientifica Retinoblastoma ed Oncologia Oculare (ASROO) – scientific manager and founding member

Honors and Awards

• SOM National Award for young ophthalmologists (1982)
• International award “Chibret International (MS&D)” for Research in Ophthalmology (1990)
• Inner Wheel Woman award” (Siena) for professional merits in Medicine (2009)
• “Exaliptron award” for global excellence in paediatric ophthalmic oncology (2017)
• SOI National Award for “Melphalan procedure: a selective therapy for retinoblastoma”

Direction or participation to research group activities involved in national or international collaborations:

• Current National SOI expert: National expert for Ocular Oncology (2004 to present)
• Representative ophthalmologist for National AIEOP Retinoblastoma Protocol (RB05) (2005-2010)
• Representative ophthalmologist for National AIEOP Retinoblastoma Protocol (RB012)
• (2012-2018)
• Current representative ophthalmologist for National AIEOP Retinoblastoma Protocol (RB018)
• Vice-Precident at OOG (Ophthalmic Oncology Group) – Liverpool (from 2014 to 2016)

Responsibilities in studies and scientific researches entrusted by qualified public or private institutions:

• Granting Agency – Istituto Toscano Tumori: “Molecular determinants of variable expressivity in Retinoblastoma.” (2007-2009) Scientific responsibilities for international or national funded research projects based on competitive calls, through peer-reviewing processes:
• CNR (Consiglio Nazionale delle Ricerche): Co-supervisor in Funded aimed project (1,2 mil); Supervisors Proff. Renato FREZZOTTI & Piero TOSI; title “Retinoblastoma”. (1993-1994)
• European Research: Co-supervisor in a European Commission funded research project (500 mil); Supervisor Prof. Renato FREZZOTTI; program “Biomedical and Health Research” (BIOMEDI) title: “The use of single chain-fv recombinant antibodies”. (1994-1995)
• Co-supervisor in funded research project (10 mil); Supervisor Prof. Renato FREZZOTTI; title “Retinoblastoma prognostic factors monitoring on clinic, morphological, immunophenotypical and molacular parameters bases”. (1995)
• Tuscany Region: Sanitary aimed research; title “Molecular genetic characterization and prenatal diagnosis of retinoblastoma through DNA analysis”. (1998-1999)
• MIUR (PRIN – ex 40%): Co-responsible in funded project (124 mil); Principal Investigator Prof. Renato FREZZOTTI; title “Genotype-phenotype correspondence in hereditary primary and open-angle glaucoma”. (1999-2000)
• PaedCan – ERN – RETINOBLASTOMA (European Projet) (2016)
• First Clinical Study Protocol of the European Retinoblastoma Group (EuRbG Recurrent Retinoblastoma 2017)”A phase II prospective international multicenter randomized clinical trial for intravitreous chemotherapy in eyes with relapsed retinoblastoma” (2017)
• Tuscany Region: Research-Health Call; role: Principal Investigator as Project Coordinator; Project title: “Development of new strategies for saving eye in retinoblastoma relapse”; Project acronym: “Liquid Eye” (2018)

Books:

• Mastrangelo D., Squitieri N., Hadjistilianou T.: La biologia e la genetica molecolare nell’oncologia oftalmologica. Tipografia Senese, 1995.
• Hadjistilianou T.: Retinoblastoma e Rabdomiosarcoma. In: Oncologia Oculare. Monografie della Societa’ Oftalmologica Italiana. I.N.C Editore. Anno XI – N. 1. 115, 136. 1999 ISSN 1121-9440
• Newsham I., Hadjistilianou T., Cavenee W.K.: Retinoblastoma in: “The metabolic and molecular bases of inherited disease”. Chapter 31, 819 – 848, vol. I, McGraw – Hill Editor, 2001.
• Newsham I., Hadjistilianou T., Cavenee W.K.: Retinoblastoma in: The genetic Basis of Human Cancer, Second Edition, Chapter 22, pag. 357-387, Mac Graw Hill, 2002
• Cavenee W.K., Hadjistilianou T., Newsham I. Retinoblastoma Syndrome. In: “World Health Organization Classification of Tumors-Pathology and genetics – Tumors of soft tissue and bone.” 363-364. LYON: IARCPress, 2002
• Karcioglu Z.A., Hadjistilianou T. Malignant Pediatric Tumors. In Orbital Tumors: Diagnosis and Treatment. Chapter 26, 304-314, Springer Edition, 2005
• Karcioglu ZA, Hadjistilianou T. Ocular Tumors. In Orbital Tumors: Diagnosis and Treatment. Chapter 22, 257-265, Springer Edition, 2005
• Renato Frezzotti, Roberto Guerra. Hadjistilinou T. “Oftalmologia Essenziale” Casa Editrice Ambrosiana seconda edizione, 2006
• Hadjistilianou, D., Karcioglu, Z.A. Ocular tumors (2015) Orbital Tumors: Diagnosis and Treatment, Second Edition, pp. 293-303
• T.Hadjistilianou. INTRAARTERIAL CHEMOTHERAPY FOR RETINOBLASTOMA – CHAPTER 98 page 823- 830. IN: Expert Techniques in Ophthalmic Surgery.JAYPEE The Health Sciences Publisher, 2015
• Karcioglu, Z.A., Hadjistilianou, D. Malignant pediatric tumors (2015) Orbital Tumors: Diagnosis and Treatment, Second Edition, pp. 349-359. Cavenee, W.K., Bogler, O., Hadjistilianou, T., Newsham, I.F. Retinoblastoma syndrome (2013) World Health Organization Classification of Tumours of Soft Tissue and Bone, pp. 388-390. Hadjistilianou T., Girolamo M.M., Десятилетний опыт интраартериальной ретинобластомы центра г. Сиена (Италия) -chapter 18- IN: Бобровой Н. Ф., РЕТИНОБЛАСТОМА (2020) Hadjistilianou T., Bracco S., Barchitta M., Intra-arterial chemotherapy for Retinoblastoma: A Team Effort – Chapter n- IN: Bhavna C., Global Perspectives in Ocular Oncology (IN PRESS)